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What You Need to Know About Guanfacine

Written byDesiree Smith

Mental health awareness is more crucial now than ever, with a growing understanding that mental disorders are just as important to treat as physical ailments. Among these disorders, attention deficit hyperactivity disorder (ADHD) is one that affects both children and adults, causing difficulties in paying attention, controlling impulsive behaviors, and being overly active. One medication that has proven effective in managing these symptoms is Guanfacine, known by its brand name, Intuniv.

What Is Guanfacine?

Guanfacine plays an essential role in the management of ADHD symptoms. This medication falls under a category of drugs known as alpha-2a adrenergic receptor agonists. Guanfacine, in its extended-release form (Intuniv), is approved for treating ADHD in children aged 6 to 17. However, doctors may also prescribe it "off-label" for adults with ADHD, making it a vital player in managing this condition across various age groups.

How Does It Work?

Guanfacine works by interacting with the alpha-2a receptors in the brain, helping to increase the brain's inhibitory capacity. In simpler terms, Guanfacine helps to "tone down" the overactivity in the brain that is often associated with ADHD.

The primary benefit of Guanfacine is the reduction of ADHD symptoms, such as inattention, hyperactivity, and impulsivity. Patients may find it easier to focus, complete tasks, and control impulsive behaviors. These improvements can lead to better social interactions and academic or workplace performance, enhancing the quality of life for those with ADHD.

How Long Does It Take To Work?

On average, patients might start to see improvements in ADHD symptoms within 2 to 4 weeks of starting Guanfacine. However, this timeline can vary from person to person.

Adverse Reactions to Guanfacine

While Guanfacine is generally well-tolerated, it can cause side effects. These may include drowsiness, fatigue, dry mouth, or stomach pain. It's also important to note that, although rare, Guanfacine can lower blood pressure and slow the heart rate. This is why it's vital to discuss any existing heart conditions or other health concerns with your healthcare provider before starting this medication.

Who Will Guanfacine Work For?

Guanfacine is typically prescribed for children aged 6 to 17 diagnosed with ADHD. It can also be prescribed off-label for adults with ADHD. However, it may not be suitable for everyone. For instance, individuals with a history of low blood pressure, slow heart rate, or other heart problems should use caution. As with any medication, it's essential to discuss your medical history and current health status with your doctor before starting Guanfacine.

Alternatives to Guanfacine

While Guanfacine can be effective for many, it’s not the only treatment option for ADHD. Other non-stimulant medications like Atomoxetine (Strattera) and Clonidine (Kapvay) could be alternatives, as well as stimulant medications like Methylphenidate (Ritalin, Concerta) or Amphetamines (Adderall, Vyvanse). Furthermore, behavioral therapies can be a valuable part of ADHD management.

The Takeaway

In conclusion, managing ADHD involves a tailored approach, considering the unique needs of each individual. Guanfacine (Intuniv) is one option that may help manage ADHD symptoms effectively. It's always important to consult with your healthcare provider to discuss the best treatment plan for you or your child.


American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). Arlington, VA: Author.

National Institute of Mental Health. (2020). Mental Health Information. Retrieved from

Sallee FR. (2009). The Role of Alpha2-Adrenergic Agonists in Attention-Deficit/Hyperactivity Disorder. Postgraduate Medicine, 121(5), 39–49. doi: 10.3810/pgm.2009.09.2050.

Guanfacine. (2019). In LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases. Retrieved from

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